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Related Concept Videos

Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
415
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

267
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
267
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

728
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
728
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
475
Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

692
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
692
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

298
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Updated: Aug 26, 2025

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Ulcerated Tophaceous Gout.

Hovra Zahoor1, Ronak Patel2, Jessica El-Bahri1

  • 1Internal Medicine, HCA Orange Park Hospital, Orange Park, USA.

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|October 7, 2022
PubMed
Summary
This summary is machine-generated.

Tophaceous gout, a chronic condition involving monosodium urate crystal deposits, can rarely lead to skin ulceration. This case report details the management of a patient with severe, ulcerated tophi, contributing to limited medical knowledge.

Keywords:
gout crystalsmanagement of ulcerated tophitophaceous goutulcerated tophaceous goutulcerated tophi

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Area of Science:

  • Rheumatology
  • Dermatology
  • Crystal Arthropathies

Background:

  • Gout is a crystal arthropathy caused by monosodium urate (MSU) crystal deposition.
  • Tophaceous gout involves chronic MSU crystal accumulation in joints and soft tissues.
  • Skin ulceration of tophi is an exceptionally rare complication.

Observation:

  • A 46-year-old male presented with poorly controlled polyarticular tophaceous gout.
  • The patient exhibited ulcerated tophi, a rare manifestation of the disease.
  • Clinical data and management strategies for this specific complication are scarce.

Findings:

  • The case highlights the challenges in managing advanced tophaceous gout with ulcerated tophi.
  • Limited literature exists on the clinical course and established treatment protocols for this rare condition.
  • This presentation underscores the need for further research into effective therapeutic approaches.

Implications:

  • Contributes to the understanding of a rare complication of gout.
  • May inform the development of improved management strategies for ulcerated tophi.
  • Emphasizes the importance of comprehensive patient care in complex cases of crystal arthropathy.