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Updated: Aug 26, 2025

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
[Research advances in post-tuberculosis lung disease]
Abstract:
The burden of tuberculosis remains high in China. Although successfully cured of tuberculosis, a large proportion of patients still suffer from post-tuberculosis lung disease (PTLD), causing great harm to individuals and societies. PTLD is a group of heterogeneous disorders that affects airways, lung parenchyma, pleura, and/or pulmonary vasculature. The related etiology and pathogenesis remain unclear, and are likely the result of the interplay between the host immune responses, pathogens, and environmental factors. Advances in prevention and treatment mainly involve adjuvant therapy and pulmonary rehabilitation. Since PTLD patients mostly visit respiratory departments for consultation, it is essential for respiratory physicians to improve the awareness PTLD, and therefore the research progress of PTLD is reviewed.
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