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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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Urinary microbiota and prostatic diseases: the key for the lock? A systematic review
Georges Mjaess1, Aya Karam2, Thierry Roumeguère3
1Department of Urology, Hôpital Universitaire de Bruxelles, Erasme hospital and Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium. georges.mjaess@ulb.be.
Prostate Cancer and Prostatic Diseases
|October 8, 2022
Summary
The urinary microbiota plays a role in benign prostatic hyperplasia (BPH), prostate cancer (PCa), and chronic prostatitis (CP). Alterations in urinary microbial composition are linked to disease severity and progression in these prostatic conditions.
Area of Science:
- Urology
- Microbiology
- Oncology
Background:
- The urinary tract harbors a complex microbiota implicated in various diseases.
- Prostatic diseases, including benign prostatic hyperplasia (BPH), prostate cancer (PCa), and chronic prostatitis (CP), are significant health concerns.
- Understanding the role of the urinary microbiota in these conditions is crucial for developing targeted therapies.
Approach:
- A systematic review and meta-analysis was conducted, searching PubMed/Medline from inception to June 2022.
- Studies investigating urinary microbiota in BPH, PCa, and CP were selected following PRISMA guidelines.
- Bacterial composition, including phylum, family, genus, and species, was analyzed in patients and controls, with study quality assessed using the CASP checklist.
Key Points:
- In BPH, altered urinary microbiota composition correlates with increased lower urinary tract symptom severity.
- Specific bacterial taxa were found to be more abundant in prostate cancer patients, with some predicting higher disease grade.
- Chronic prostatitis cases exhibited distinct microbiota compositions and higher diversity, with aerobic microorganisms influencing symptom severity.
Conclusions:
- The urinary microbiota is demonstrably implicated in the pathogenesis and progression of BPH, PCa, and CP.
- While significant associations exist, heterogeneity among studies necessitates further research for precise delineation.
- Future investigations are required to validate these findings and explore the therapeutic potential of modulating the urinary microbiome.
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