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Atrial depolarization abnormalities in pulmonary sarcoidosis
Amal Paul1,2, Akhil Paul3, Immanuel Subhash3
1Department of Cardiology, Christian Medical College and Hospital (CMCH), Vellore, India. look_lama@yahoo.co.in.
Summary
Subtle electrocardiogram (ECG) abnormalities are more common in pulmonary sarcoidosis patients. Specific atrial depolarization changes, like biphasic and bifid P waves, were frequently observed, aiding early cardiac sarcoidosis detection.
Area of Science:
- Cardiology
- Pulmonology
- Medical Diagnostics
Background:
- Cardiac sarcoidosis can present as sudden death and is often the initial manifestation of sarcoidosis.
- 12-lead electrocardiogram (ECG) is a crucial screening tool for cardiac sarcoidosis.
- Identifying subtle ECG abnormalities is significant for early diagnosis.
Purpose of the Study:
- To identify specific electrocardiographic abnormalities in patients diagnosed with pulmonary sarcoidosis.
- To compare ECG findings in pulmonary sarcoidosis patients with a healthy control group.
Main Methods:
- Analysis of 12-lead ECGs from sixty patients with histopathologically confirmed pulmonary sarcoidosis and no overt cardiac involvement.
- Comparison of ECG findings with an age-matched control group.
Main Results:
- Intraventricular conduction defects were prevalent in both study (67%) and control (57%) groups (P=0.23).
- Higher prevalence of biphasic P wave (P=0.003) and bifid P wave (P=0.029) in lead III observed in the study group.
- Increased incidence of rsr' in lead aVF (P=0.03) noted in pulmonary sarcoidosis patients compared to controls.
Conclusions:
- Pulmonary sarcoidosis patients exhibit a higher prevalence of subtle ECG abnormalities than those with other pulmonary diseases.
- Atrial depolarization abnormalities are more common in individuals with pulmonary sarcoidosis.
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