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White matter hyperintensities and post-stroke depression: A systematic review and meta-analysis
Feng Zhang1, Yukun Ping1, Xuejiao Jin1
1Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, China; Henan Key Lab of Biological Psychiatry, Henan International Joint Laboratory of Psychiatry and Neuroscience, Xinxiang Medical University, China.
Journal of Affective Disorders
|October 9, 2022
Summary
Periventricular white matter hyperintensities (PVWMHs) are significantly associated with post-stroke depression (PSD), especially in the chronic phase. Other white matter hyperintensities (WMHs) also show links to PSD later after stroke.
Area of Science:
- Neurology
- Neuroimaging
- Psychiatry
Background:
- Post-stroke depression (PSD) is a common complication following stroke.
- White matter hyperintensities (WMHs), including deep (DWMHs) and periventricular (PVWMHs) types, are frequently observed in stroke patients.
- The association between WMHs and PSD is not fully understood.
Purpose of the Study:
- To systematically review and synthesize the evidence on the relationship between WMHs and PSD.
- To clarify the controversial findings regarding WMHs as risk factors for PSD.
Main Methods:
- A systematic literature search was performed across electronic databases.
- Data from eligible studies were extracted, and study quality was assessed using the Newcastle-Ottawa Scale.
- Pooled odds ratios (OR) were calculated for different types of WMHs and PSD across stroke phases.
Main Results:
- In the acute phase, only PVWMHs and severe PVWMHs were significantly associated with PSD.
- In the subacute phase, PVWMHs showed a significant association with PSD.
- In the chronic phase, WMHs, DWMHs, PVWMHs, and severe DWMHs were significantly associated with PSD, with PVWMHs demonstrating a stronger correlation.
Conclusions:
- WMHs, DWMHs, and PVWMHs are significantly associated with PSD in the chronic post-stroke phase.
- PVWMHs exhibit a stronger correlation with PSD across all post-stroke periods compared to WMHs and DWMHs.
- Further high-quality prospective studies are required to definitively establish the relationship between WMHs and PSD.
