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Pharmacologic Therapy for Heart Failure with Preserved Ejection Fraction
Anthony E Peters1, Adam D DeVore1
1Division of Cardiology, Duke University School of Medicine, Duke University Medical Center, 200 Trent Drive, 4th Floor, Orange Zone, Room #4225, Durham, NC 27710, USA; Duke Clinical Research Institute, Duke University Medical Center, 200 Trent Drive, 4th Floor, Orange Zone, Room #4225, Durham, NC 27710, USA.
Abstract:
The management of heart failure with preserved ejection fraction (HFpEF) is rapidly evolving. The pharmacologic treatment of patients with HFpEF includes symptom management with diuretics and optimization of comorbidities, including hypertension, obesity, diabetes mellitus, and atrial fibrillation. Specific therapies, including angiotensin II receptor blockers, mineralocorticoid receptor antagonists, angiotensin receptor-neprilysin inhibitors, and sodium-glucose cotransporter-2 inhibitors, are well tolerated and can reduce the risk of HF hospitalization, particularly in those on the lower end of the HFpEF left ventricular ejection fraction spectrum. Ongoing trials should continue to inform optimal therapy in this evolving field.
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