Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Expiratory flow pattern and respiratory mechanics.

J P Mortola, A M Lauzon, B Mott

    Canadian Journal of Physiology and Pharmacology
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Airway Epithelial Cells Drive Airway Smooth Muscle Cell Phenotype Switching to the Proliferative and Pro-inflammatory Phenotype.

    Frontiers in physiology·2021
    Same author

    Parasaccharibacter apium, gen. nov., sp. nov., Improves Honey Bee (Hymenoptera: Apidae) Resistance to Nosema.

    Journal of economic entomology·2016
    Same author

    Characterization of a submillimeter high-angular-resolution camera with a monolithic silicon bolometer array for the Caltech Submillimeter Observatory.

    Applied optics·2010
    Same author

    Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.

    The European respiratory journal·2007
    Same author

    Mechanics of the respiratory system in the newborn tammar wallaby.

    The Journal of experimental biology·2002
    Same author

    Circadian patterns in men acclimatized to intermittent hypoxia.

    Respiration physiology·2001
    Same journal

    Next-generation therapeutics and renaissance of legacy drugs targeting the endothelin system.

    Canadian journal of physiology and pharmacology·2026
    Same journal

    Exploring the causal relationship between inflammatory cytokines and diabetic foot ulcer: A bidirectional Mendelian randomization and clinical validation study.

    Canadian journal of physiology and pharmacology·2026
    Same journal

    TRPV1, Endocannabinoid, and Opioid Systems in Analgesia: Molecular Mechanisms and Drug Development Strategies.

    Canadian journal of physiology and pharmacology·2026
    Same journal

    Association of stromal cell derived factor 1α and interferon-γ induced protein 10 with Fontan pathophysiology.

    Canadian journal of physiology and pharmacology·2026
    Same journal

    Incretins for Type 2 Diabetes.

    Canadian journal of physiology and pharmacology·2026
    Same journal

    Glucagon-like peptide 1 receptor agonists: anti-inflammatory effects in cardiovascular diseases.

    Canadian journal of physiology and pharmacology·2026
    See all related articles

    Expiratory vocal fold narrowing, common in newborns, minimally impacts respiratory system impedance. This suggests expiratory patterns regulate airway pressure for lung fluid balance and gas exchange, not to reduce breathing effort.

    Area of Science:

    • Physiology
    • Respiratory Mechanics
    • Neonatal Physiology

    Background:

    • Expiration involves vocal fold narrowing, increasing expiratory resistance, lung volume, and airway pressure.
    • Neonatal expirations often feature short, complete airway closures, amplifying these effects.
    • The functional significance of expiratory flow patterns on inspiratory respiratory system impedance is not fully understood.

    Purpose of the Study:

    • To investigate how different expiratory flow patterns affect the inspiratory impedance of the respiratory system.
    • To determine if expiratory loading influences respiratory system compliance and impedance in newborn and adult animals.

    Main Methods:

    • Anesthetized, paralyzed, and mechanically ventilated newborn puppies, piglets, and adult rats.
    • Ventilation with three distinct expiratory patterns: no expiratory load, expiratory resistive load, and end-inspiratory pause.

    Related Experiment Videos

  • Measurements of mean inspiratory impedance and compliance after 1 minute of each ventilatory pattern, ensuring consistent starting lung volumes.

    • Main Results:

    • Changes in expiratory flow patterns (no load, resistive load, end-inspiratory pause) resulted in unchanged or minimally altered inspiratory impedance and compliance.
    • The type of expiratory ventilation did not significantly impact the measured respiratory parameters.

    Conclusions:

    • Expiratory laryngeal loading does not primarily serve to decrease the work of breathing.
    • Expiratory patterns likely play a role in increasing and controlling mean airway pressure.
    • This control of mean airway pressure may be crucial for regulating pulmonary fluid reabsorption, ventilation distribution, and gas diffusion.