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Area of Science:

  • Dermatology
  • Cosmetology
  • Toxicology

Background:

  • Vitamins are essential bioactive compounds with antioxidant properties.
  • Synthesized vitamin derivatives are increasingly used in cosmetics.
  • This has led to a rise in allergic contact dermatitis (ACD) cases.

Purpose of the Study:

  • To review the sensitizing role of vitamins in cosmetic products.
  • To provide insights into vitamin-induced allergic contact dermatitis.
  • To suggest potential patch test alternatives for diagnosis.

Main Methods:

  • Systematic literature review following PRISMA guidelines.
  • Searched Medline, PubMed, Scopus, EMBASE, and Google Scholar (1940-2021).
  • Included 104 relevant articles reporting on vitamin-induced ACD.

Main Results:

  • ACD from vitamins in cosmetics is likely underestimated.
  • Most vitamins in topical products can induce allergic reactions.
  • Vitamin B2 and B9 are exceptions, not typically causing ACD.

Conclusions:

  • Vitamins in cosmetics, perceived as safe, can cause ACD.
  • Non-standardized patch tests complicate ACD diagnosis.
  • Further research and diagnostic standardization are needed.