Related Experiment Video
Updated: Aug 26, 2025

Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
An update on advanced therapies for Parkinson's disease: From gene therapy to neuromodulation
Stephanie N Serva1, Jacob Bernstein2, John A Thompson2,3
1School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Abstract:
Advanced Parkinson's disease (PD) is characterized by increasingly debilitating impaired movements that include motor fluctuations and dyskinesias. At this stage of the disease, pharmacological management can result in unsatisfactory clinical benefits and increase the occurrence of adverse effects, leading to the consideration of advanced therapies. The scope of this review is to provide an overview of currently available therapies for advanced PD, specifically levodopa-carbidopa intestinal gel, continuous subcutaneous apomorphine infusion, radiofrequency ablation, stereotactic radiosurgery, MRI-guided focused ultrasound, and deep brain stimulation. Therapies in clinical trials are also discussed, including novel formulations of subcutaneous carbidopa/levodopa, gene-implantation therapies, and cell-based therapies. This review focuses on the clinical outcomes and adverse effects of the various therapies and also considers patient-specific characteristics that may influence treatment choice. This review can equip providers with updated information on advanced therapies in PD to better counsel patients on the available options.
More Related Videos
Related Concept Videos
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease: Overview
Gene Therapy
Microorganisms in Medicine and Therapeutics
Alzheimer's Disease: Treatment
Neural Regulation

