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Updated: Jul 16, 2026
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Stimulation-Related Increases in Power Spectral Density Covary With Clinical Evidence of Overstimulation During Deep
Madelyn Pascual1, Pritha Bisarad2, James Kelbert2
1Pediatric Movement Disorders Program, Department of Neurology, Barrow Neurological Institute, Phoenix Children's, Phoenix, Arizona, USA.
Background:
Patients with dystonia undergoing deep brain stimulation (DBS) often require individualized stimulation settings. Although effective settings reduce dystonia, excessive stimulation can worsen symptoms. Assessing DBS effects during office visits is challenging, as clinical changes can be delayed hours to days.
Objectives:
We evaluated whether local field potentials (LFPs) could serve as an acute biomarker of excessive stimulation in dystonia patients.
Materials And Methods:
Real-time LFP band power and dystonia severity were quantified and compared during sequential changes in stimulation amplitude.
Results:
Increased stimulation current amplitude led to patient-specific LFP band power increase which was temporally aligned and correlated with clinically evident dystonia worsening, in all subjects, during in-office DBS programming sessions.
Conclusions:
Although increased LFP band power correlated with clear clinical worsening in these patients, we anticipate that not all patients with dystonia will have such immediate signs of worsening. Increased LFP band power during incremented stimulation amplitude may represent a biomarker for patients at-risk of manifesting delayed clinical worsening.
