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Gray-Matter Morphometry of Internalizing-Symptom Dimensions During Adolescence
Harry R Smolker1, Hannah R Snyder2, Benjamin L Hankin3
1Institute of Cognitive Science, University of Colorado Boulder.
Summary
This study reveals distinct brain anatomy patterns linked to adolescent internalizing psychopathology dimensions, including visual processing areas. Findings differed significantly between males and females, with effects often opposite to those in adults and children.
Area of Science:
- Neuroscience
- Developmental Psychology
- Psychiatry
Background:
- Adolescence is a critical period for mental illness onset.
- Internalizing psychopathology is common in adolescents.
- Neurodevelopmental changes during adolescence impact mental health.
Purpose of the Study:
- To identify neuroanatomical correlates of internalizing psychopathology dimensions in adolescents.
- To examine co-occurring and dissociable features of internalizing symptoms.
- To investigate sex differences in these neuroanatomical associations.
Main Methods:
- Utilized neuroimaging techniques to analyze brain structure.
- Employed statistical methods to correlate brain anatomy with symptom dimensions.
- Examined four dimensions: common internalizing, low positive affect, anxious arousal, and anxious apprehension residuals.
Main Results:
- Internalizing psychopathology dimensions associate with widespread neuroanatomy, including prefrontal, limbic, and visual processing regions.
- Significant sex differences were observed in neuroanatomical correlates.
- Observed effects in adolescents were often opposite to those in children and adults.
Conclusions:
- Adolescent internalizing psychopathology is associated with specific neuroanatomical patterns.
- Sex differences in neurodevelopment influence vulnerability to internalizing disorders.
- These findings highlight the unique neurodevelopmental trajectory of internalizing disorders during adolescence.
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