Related Experiment Video

Updated: Aug 26, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K

The Atherogenic Index of Plasma is Associated With Cerebral Small Vessel Disease: A Cross-Sectional Study

Ki-Woong Nam1,2, Hyung-Min Kwon1,2, Jin-Ho Park3,4

  • 1Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.

Journal of Lipid and Atherosclerosis
|October 10, 2022
PubMed

Insights

High Atherogenic Index of Plasma (AIP) is linked to cerebral small vessel disease (cSVD) subtypes like white matter hyperintensity and lacunes in health check-up participants. This suggests an atherosclerosis-related pathology may underlie these conditions.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Atherogenic dyslipidemia is increasingly recognized in cerebrovascular diseases.
  • The Atherogenic Index of Plasma (AIP) offers a single metric for this lipid profile.
  • Limited research exists on AIP's role in cerebrovascular disease.

Purpose of the Study:

  • To investigate the association between AIP and cerebral small vessel disease (cSVD).
  • To analyze AIP's relationship with specific cSVD subtypes: white matter hyperintensity (WMH), lacunes, and cerebral microbleeds (CMBs).

Main Methods:

  • Retrospective analysis of 3,170 health check-up participants (2006-2013).
  • cSVD assessment included quantitative WMH volume and qualitative lacunes and CMBs.
  • AIP calculated as log [triglyceride/high-density lipoprotein cholesterol].

Main Results:

  • AIP showed a significant association with WMH volume (β=0.129) and lacunes (adjusted OR=1.72-1.79).
  • Age, hypertension, diabetes, lipid-lowering agents, and intracranial atherosclerosis were also linked to WMH.
  • Age and intracranial atherosclerosis were associated with lacunes.
  • No significant association was found between AIP and CMBs.

Conclusions:

  • Elevated AIP is associated with cSVD, specifically WMH and lacunes, in health check-up participants.
  • The findings suggest that atherosclerosis-related pathology may contribute to WMH and lacunes.
  • Further research is warranted to explore the clinical implications of AIP in cerebrovascular health.
Abstract

Keywords:
AtherosclerosisCerebrovascular diseaseCholesterolDyslipidemiaTriglyceride

More Related Videos

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.4K
Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.2K

Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
31
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
44
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
46
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
24
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
26
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
24