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Body shape and risk of glaucoma: A Mendelian randomization
Ruolan Yuan1,2, Kangcheng Liu3, Yingjun Cai1,2
1Eye Center of Xiangya Hospital, Hunan Key Laboratory of Ophthalmology, Central South University, Changsha, China.
Frontiers in Medicine
|October 10, 2022
Summary
Increased body mass index (BMI) and waist circumference (WC) are linked to higher glaucoma risk. Other body size measures like WHRadjBMI and WHR showed no significant association with glaucoma development.
Area of Science:
- Ophthalmology
- Genetics
- Public Health
Background:
- Body size is a known risk factor for various diseases, but its association with glaucoma remains debated.
- Investigating the genetic link between body size and glaucoma is crucial for understanding disease etiology.
Purpose of the Study:
- To investigate the causal relationship between body size and glaucoma risk using a Mendelian randomization approach.
- To determine if specific anthropometric traits influence glaucoma development at a genetic level.
Main Methods:
- Utilized a two-sample Mendelian randomization analysis on genome-wide association study data.
- Employed three MR methods (IVW, Weighted median, MR-Egger) to assess the causal effect of body size on glaucoma.
- Analyzed data from the GIANT consortium and FinnGen study, including 8,591 glaucoma cases and 210,201 controls.
Main Results:
- Elevated body mass index (BMI) was associated with an increased risk of glaucoma (OR = 1.20; P = 0.03).
- Increased waist circumference (WC) also showed a significant association with higher glaucoma risk (OR = 1.32; P = 0.03).
- Genetically predicted WHRadjBMI and WHR were not significantly associated with glaucoma risk.
Conclusions:
- Increased BMI and WC are identified as potential risk factors for glaucoma.
- WHRadjBMI and WHR do not appear to be associated with glaucoma development.
- The findings suggest a specific role for certain body size metrics in glaucoma pathogenesis.
Keywords:
Mendelian randomizationbody mass indexbody shapeglaucomawaist circumferencewaist-to-hip ratiowaist-to-hip ratio adjusted by body mass indexMore Related Videos
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