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Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
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Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
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An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
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Scalable Approximate Bayesian Computation for Growing Network Models via Extrapolated and Sampled Summaries.

Louis Raynal1, Sixing Chen1, Antonietta Mira2,3

  • 1Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, 655 Huntington Avenue, Building 2, 4th Floor, Boston, MA, USA 02115.

Bayesian Analysis
|October 10, 2022
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Approximate Bayesian computation (ABC) for large network models is improved by extrapolating summary statistics and using sampled statistics. This makes ABC inference more efficient for growing network models.

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Gaussian processmechanistic modelsnetwork models

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Area of Science:

  • Computational Statistics
  • Network Science
  • Statistical Inference

Background:

  • Approximate Bayesian computation (ABC) is a powerful simulation-based, likelihood-free inference method.
  • ABC is computationally intensive, especially for large datasets and complex models like growing networks.
  • Existing ABC methods struggle with the scale and computational demands of mechanistic network growth models.

Purpose of the Study:

  • To develop novel methodological approaches for enabling Approximate Bayesian computation (ABC) in large growing network models.
  • To enhance the computational efficiency of ABC for parameter estimation and model selection in network science.
  • To address the limitations of traditional ABC methods when dealing with large-scale, incrementally generated data.

Main Methods:

  • Proposed a procedure to extrapolate summary statistics from small to large networks using least squares and Gaussian processes.
  • Introduced the use of sample-based summary statistics instead of census-based ones to reduce computational cost.
  • Applied these methods to mechanistic models of network growth.

Main Results:

  • The developed methods significantly reduce the computational burden of ABC for large growing networks.
  • The resulting ABC posterior distribution closely approximates the posterior from standard, computationally expensive ABC methods.
  • Extrapolated and sampled summary statistics proved effective for inference in large network models.

Conclusions:

  • The proposed methodological advancements make ABC a more feasible and efficient tool for inferring parameters in large, growing network models.
  • These techniques of summary statistic extrapolation and sampling offer broader applicability to other incremental data generation scenarios in ABC.
  • The study bridges a gap in statistical inference tools for complex network models.