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Related Experiment Video

Updated: Aug 26, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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Genomics and Pediatric Sepsis.

Axel Moreira, Parag Jain

    Pediatric Annals
    |October 10, 2022
    PubMed
    Summary

    Sepsis, a life-threatening infection response, shows varied severity. Bioinformatics reveals distinct sepsis endotypes, paving the way for targeted therapies beyond antibiotics.

    Area of Science:

    • Immunology
    • Bioinformatics
    • Critical Care Medicine

    Background:

    • Sepsis is a complex clinical syndrome resulting from immune system dysregulation following infection.
    • Sepsis severity ranges from mild symptoms to severe multiorgan failure and death.
    • Recent advances in bioinformatics have identified distinct sepsis endotypes.

    Purpose of the Study:

    • To understand the pathophysiologic mechanisms underlying different sepsis endotypes.
    • To explore how knowledge of sepsis endotypes can inform future therapeutic strategies.

    Main Methods:

    • Utilizing bioinformatics to analyze large-scale datasets related to sepsis.
    • Characterizing distinct patient subgroups (endotypes) based on molecular and clinical data.

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    Related Experiment Videos

    Last Updated: Aug 26, 2025

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    A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

    Published on: August 12, 2020

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    A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
    14:54

    A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

    Published on: January 27, 2019

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    A Data-Driven Approach to Quantifying Immune States in Sepsis
    07:42

    A Data-Driven Approach to Quantifying Immune States in Sepsis

    Published on: February 7, 2025

    302

    Main Results:

    • Elucidation of specific molecular signatures associated with different sepsis endotypes.
    • Demonstration of variability in immune system dysregulation across endotypes.

    Conclusions:

    • Understanding sepsis endotypes is crucial for developing precise, adjunct therapies.
    • Future treatments for sepsis may be tailored to specific endotypes, improving patient outcomes.