Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.1K
Gene-Environment Interactions01:20

Gene-Environment Interactions

413
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
413
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.0K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.0K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

1.9K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.9K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

23.6K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
23.6K
Position-effect Variegation02:32

Position-effect Variegation

6.5K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abrogation of Oncogenic RAS Signaling by a RAS(ON) Inhibitor Doublet Primes Immune-Refractory KRASG12C-Mutant NSCLC for Immune Checkpoint Blockade.

Cancer discovery·2026
Same author

The interaction between dynamic ligand signaling and epigenetics in Notch-induced cancer metastasis.

Physical biology·2025
Same author

Emergent dynamics of cellular decision making in multi-node mutually repressive regulatory networks.

Journal of the Royal Society, Interface·2025
Same author

Constraints and tunability of antigen-agnostic memory durability.

bioRxiv : the preprint server for biology·2025
Same author

Cumulative dose responses for adapting biological systems.

Journal of the Royal Society, Interface·2025
Same author

PROFET Predicts Continuous Gene Expression Dynamics from scRNA-seq Data to Elucidate Heterogeneity of Cancer Treatment Responses.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Aug 26, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

35.9K

Epigenetic factor competition reshapes the EMT landscape.

M Ali Al-Radhawi1,2, Shubham Tripathi2,3,4, Yun Zhang5,6

  • 1Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115.

Proceedings of the National Academy of Sciences of the United States of America
|October 10, 2022
PubMed
Summary

Epigenetic regulators influence cell phenotypes through complex interactions. This study introduces a new model accounting for both local and global epigenetic competition, explaining puzzling data on epithelial-mesenchymal transition (EMT).

Keywords:
EMTepigeneticgene network

More Related Videos

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

13.2K
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.5K

Related Experiment Videos

Last Updated: Aug 26, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

35.9K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

13.2K
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.5K

Area of Science:

  • Cellular biology
  • Systems biology
  • Epigenetics

Background:

  • Phenotypic transitions in isogenic cells arise from epigenetic marks, signals, and gene-regulatory elements.
  • Gene-regulatory networks (GRNs) model these complex interactions, but often overlook global epigenetic factor competition.

Purpose of the Study:

  • To develop a conceptual and mathematical framework for modeling epigenetic regulation.
  • To incorporate local and global competition effects of epigenetic regulators and transcription factors.

Main Methods:

  • Developed a novel modeling framework integrating local and global epigenetic competition.
  • Applied the framework to analyze experimental data on epithelial-mesenchymal transition (EMT).

Main Results:

  • The model explains counterintuitive consequences of epigenetic regulator interactions.
  • The framework successfully explains puzzling experimental data on EMT.

Conclusions:

  • Accounting for global epigenetic competition is crucial for understanding phenotypic transitions.
  • The proposed model offers verifiable predictions for future experimental validation.