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Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
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Three-dimensional printed dosage forms based on disease-focussed perspectives.

Hazal Ezgi Gültekin1, Fatmanur Tuğcu Demiröz2, Serdar Tort2

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, İzmir Kâtip Çelebi University, İzmir, Turkey.

The Journal of Pharmacy and Pharmacology
|October 10, 2022
PubMed
Summary

Three-dimensional printing (3DP) offers personalized medicine potential in drug manufacturing. This review explores 3DP applications across various diseases, including cardiovascular, neurological, and oncological conditions, highlighting recent advancements.

Keywords:
3D printed dosage forms3D printingdisease focusseddrug deliverypersonalized medicine

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Area of Science:

  • Pharmaceutical Technology
  • Biomedical Engineering
  • Materials Science

Background:

  • Three-dimensional printing (3DP) is an emerging technology with significant potential in pharmaceutical manufacturing.
  • Its ability to create complex and customized dosage forms makes it ideal for personalized medicine applications.

Purpose of the Study:

  • To provide a comprehensive overview of 3DP technologies in the pharmaceutical sector.
  • To detail the working principles and critical process parameters of 3DP in drug manufacturing.
  • To explore the application of 3DP across a spectrum of diseases.

Main Methods:

  • Systematic review of scientific literature published after 2015.
  • Analysis of studies focusing on 3DP applications in various disease categories.
  • Evaluation of different 3DP methods, printer types, and resulting dosage forms.

Main Results:

  • 3DP shows promise for treating cardiovascular, neurological, respiratory, oncological, inflammatory, vaginal, and dermatological diseases.
  • Various dosage forms, including oral tablets, films, implants, topical systems, and vaccines, have been developed using 3DP.
  • The review covers research-based evaluations of 3DP's potential in diverse clinical applications.

Conclusions:

  • 3DP represents a novel and systematic approach to treating a wide range of clinical disorders.
  • The technology facilitates the development of innovative drug delivery systems tailored to individual patient needs.