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Post-translational modifications and age-related hearing loss
Parveen Bazard1, Jennifer Pineros1, Alejandro A Acosta2
1Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
Hearing Research
|October 10, 2022
Summary
Post-translational modifications (PTMs) are crucial for protein function and homeostasis. Irregularities in PTMs are linked to age-related hearing loss (ARHL), offering potential therapeutic targets.
Area of Science:
- Molecular Biology
- Cellular Biology
- Neuroscience
Background:
- Post-translational modifications (PTMs) regulate protein structure, localization, and activity, impacting cellular processes and homeostasis.
- Dysfunctional PTMs are implicated in various diseases, including neurodegenerative conditions.
- Age-related hearing loss (ARHL) is a significant communication disorder with no current FDA-approved treatments.
Purpose of the Study:
- To review the role of PTMs in the auditory system.
- To explore the connection between PTMs, aging, and ARHL.
- To discuss PTMs as potential biomarkers and therapeutic targets for ARHL.
Main Methods:
- Literature review of PTMs in the auditory system.
- Analysis of research linking PTMs to aging and hearing loss.
- Synthesis of findings on PTM-based therapeutic strategies.
Main Results:
- PTMs play a critical role in auditory system function.
- Alterations in PTMs are associated with the development of ARHL.
- PTMs represent promising avenues for ARHL biomarker discovery and treatment.
Conclusions:
- PTMs are integral to auditory health and homeostasis.
- Targeting PTM pathways may offer novel therapeutic strategies for ARHL.
- Further research into PTMs could lead to effective treatments for age-related hearing loss.
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