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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Platelet Activity and Cardiovascular Risk in CKD and Peripheral Artery Disease

Lucas B Cofer1, Qandeel H Soomro2, Yuhe Xia3

  • 1Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Kidney International Reports
|October 11, 2022
PubMed

Insights

Chronic kidney disease (CKD) increases platelet activity and cardiovascular risk in patients with peripheral artery disease (PAD). This heightened platelet aggregation partially explains the elevated risk of heart attack and major adverse cardiovascular events in CKD patients.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Hematology

Background:

  • Chronic kidney disease (CKD) is linked to platelet dysfunction and increased cardiovascular risk.
  • The precise mechanisms connecting kidney function, platelet activity, and cardiovascular disease (CVD) progression remain incompletely understood.

Purpose of the Study:

  • To investigate the association between CKD status and platelet activity.
  • To determine if increased platelet activity mediates cardiovascular risk in patients with peripheral artery disease (PAD).

Main Methods:

  • Prospective cohort study of adults with PAD undergoing lower extremity revascularization.
  • Platelet activity assessed using light transmission aggregometry (LTA).
  • Comparison of cardiovascular event incidence between CKD and non-CKD groups.

Main Results:

  • 40% of participants had CKD (eGFR < 60 ml/min/1.73 m²).
  • CKD patients exhibited higher platelet aggregation in response to ADP, serotonin, epinephrine, and AA + aspirin.
  • CKD was associated with increased risk of myocardial infarction (MI) and major adverse cardiovascular events (MACE).

Conclusions:

  • In PAD patients undergoing revascularization, CKD is linked to heightened platelet activity.
  • Increased platelet aggregation partially mediates the elevated cardiovascular risk observed in CKD patients.
Abstract

Keywords:
CKDCVDPADPlatelet activity

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