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Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
09:04

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg

Published on: November 19, 2019

Bleeding history is associated with lower risk of cardiovascular events in a cohort undergoing lower extremity

David J Bresnahan1, Yuhe Xia1, Nathaniel R Smilowitz1,2

  • 1Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.

Journal of Thrombosis and Thrombolysis
|May 29, 2026
PubMed

Patients with peripheral artery disease undergoing lower extremity revascularization remain at high risk for cardiovascular events despite intervention. This retrospective analysis of 289 participants examined the relationship between pre-procedural bleeding history and post-procedural outcomes using a modified International Society on Thrombosis and Haemostasis bleeding assessment tool. After median 18-month follow-up, participants with significant bleeding history experienced lower risk of major adverse cardiovascular events (18.4% versus 30.6%, p = 0.034) and mortality (13.6% versus 24.2%, p = 0.047). An inverse exposure-outcome relationship was observed between bleeding severity and outcomes. Bleeding history may identify patients at lower risk for thrombotic complications.

Keywords:
Bleeding historyCardiovascular eventsLower extremity revascularizationPeripheral artery diseasePlatelets

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