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Pituitary enlargement associated with Addison's disease
Clinical Radiology
|July 1, 1987
Summary
Addison's disease can cause pituitary enlargement, mimicking pituitary adenoma. Serial computed tomography (CT) scans after hormone replacement therapy are crucial for accurate diagnosis in such cases.
Area of Science:
- Endocrinology
- Neuroendocrinology
- Radiology
Background:
- Addison's disease, or primary adrenal insufficiency, involves inadequate cortisol production.
- Pituitary enlargement can occur secondary to adrenal insufficiency due to loss of negative feedback.
- Distinguishing this from primary pituitary pathology is clinically important.
Observation:
- A case presented with pituitary enlargement that initially suggested a pituitary adenoma.
- The patient had symptoms consistent with Addison's disease.
Findings:
- Serial computed tomography (CT) scans were performed.
- CT imaging after initiation of glucocorticoid replacement therapy demonstrated a reduction in pituitary size.
- This confirmed the diagnosis of pituitary enlargement secondary to Addison's disease.
Implications:
- Highlights the importance of considering secondary causes of pituitary enlargement.
- Emphasizes the diagnostic utility of serial imaging in endocrinopathies.
- Underscores the need for comprehensive evaluation to avoid misdiagnosis of pituitary adenoma.