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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Surface Membrane Barriers01:18

Surface Membrane Barriers

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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Why Does Facial Eczema Differ From Body Eczema?

Marissa Contento, Jacqueline Maher, Abigail Cline

    Journal of Drugs in Dermatology : JDD
    |October 11, 2022
    PubMed
    Summary

    Facial eczema differs from body eczema due to unique skin factors and environmental exposures on the face. Understanding these differences is key for managing atopic dermatitis (AD) and developing new treatments.

    Area of Science:

    • Dermatology
    • Immunology
    • Microbiology

    Background:

    • Atopic dermatitis (AD) pathophysiology is complex, involving genetics, skin barrier issues, and environmental factors.
    • Limited research compares the distinct causes and mechanisms of facial versus body eczema.

    Purpose of the Study:

    • To investigate the reasons behind the differences observed in facial eczema compared to body eczema.

    Main Methods:

    • Comparative analysis of facial and body skin environments.
    • Review of environmental stressors impacting facial skin.
    • Examination of topical steroid management differences.

    Main Results:

    • Facial skin exhibits unique microbiome composition, sebaceous gland concentration, and natural moisturizing factor levels.

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  • The face encounters greater environmental stress (allergens, UV, cosmetics) than the body.
  • Facial eczema management avoids potent steroids, potentially reducing microbiome diversity and worsening AD.

    • Conclusions:

    • Anatomical and environmental disparities explain facial and body eczema differences.
    • Further research into these distinctions can guide clinical management and novel AD treatment development.