Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

397
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
397
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

295
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
295
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

269
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
269
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

186
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
186
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

276
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
276
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

352
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
352

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Connecting the Dots Between Theory and Practice: Speaking With Your Patients About IBS-C Management.

Gastroenterology & hepatology·2026
Same author

Managing the Diagnostic and Therapeutic Challenges of Irritable Bowel Syndrome.

Gastroenterology & hepatology·2026
Same author

Rapid Gastric Emptying: Insights from a Large Cohort Study on a Controversial Disorder.

Digestive diseases and sciences·2026
Same author

Constipation with bloating: a clinical approach to evaluation and management.

Annals of medicine·2026
Same author

Correction to: Abdominal Symptom Improvement During Clinical Trials of Tenapanor in Patients With Irritable Bowel Syndrome With Constipation: A Post Hoc Analysis.

The American journal of gastroenterology·2026
Same author

Design of Treatment Trials for Disorders of Gut-Brain Interaction.

Gastroenterology·2026

Related Experiment Video

Updated: Aug 26, 2025

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
06:40

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

Published on: June 29, 2019

6.7K

Updates in functional dyspepsia and bloating.

Brian E Lacy1, David J Cangemi

  • 1Division of Gastroenterology & Hepatology, Mayo Clinic, Jacksonville, Florida, USA.

Current Opinion in Gastroenterology
|October 11, 2022
PubMed
Summary

New research reveals key insights into functional dyspepsia and bloating, common gastrointestinal issues. Understanding their causes and pathophysiology is driving significant advancements in patient treatment and quality of life.

More Related Videos

Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes
06:01

Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes

Published on: July 26, 2024

668
Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

529

Related Experiment Videos

Last Updated: Aug 26, 2025

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
06:40

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

Published on: June 29, 2019

6.7K
Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes
06:01

Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes

Published on: July 26, 2024

668
Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

529

Area of Science:

  • Gastroenterology
  • Digestive Health
  • Microbiome Research

Background:

  • Functional dyspepsia and bloating are prevalent gastrointestinal disorders impacting patient quality of life and healthcare resources.
  • These conditions frequently necessitate referrals to gastroenterology specialists.

Purpose of the Study:

  • To review recent significant findings regarding the etiology, pathophysiology, and therapeutic strategies for functional dyspepsia and bloating.
  • To highlight advancements that are reshaping the medical management of these common digestive complaints.

Main Methods:

  • Review of recent literature and clinical findings.
  • Analysis of data from the NIH-sponsored Gastroparesis Consortium.
  • Validation of a new questionnaire for bloating and distension assessment.
  • Meta-analysis of medications for bloating in irritable bowel syndrome with constipation.

Main Results:

  • Confocal laser endomicroscopy revealed epithelial barrier changes and duodenal inflammation linked to functional dyspepsia.
  • Gut microbiome alterations are implicated in some functional dyspepsia cases, potentially responsive to antibiotics.
  • Functional dyspepsia and gastroparesis are recognized as existing on a continuum.
  • Virtual reality emerges as a potential new therapy for functional dyspepsia.
  • A validated questionnaire aids in assessing bloating and distension symptoms and impact.
  • Effective medications for bloating in irritable bowel syndrome with constipation were identified.

Conclusions:

  • Progress in understanding the pathophysiology of functional dyspepsia and bloating is directly influencing therapeutic approaches.
  • New diagnostic insights and treatment options are emerging for these common gastrointestinal conditions.