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Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

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Published on: September 29, 2016

Mannobioside biomimetics that trigger DC-SIGN binding selectivity.

Irene Herrera-González¹, Michel Thépaut², Elena M Sánchez-Fernández¹

¹Department of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, Seville 41012, Spain. mellet@us.es.

Chemical Communications (Cambridge, England)

|October 11, 2022

Summary

This summary is machine-generated.

Multivalent sp2-iminosugar mannobioside analogs selectively target DC-SIGN, not langerin. These biomimetic compounds offer potential as novel anti-infective agents by mimicking natural ligand binding.

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Area of Science:

Carbohydrate chemistry
Immunology
Infectious diseases

Background:

Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and langerin are C-type lectins involved in pathogen recognition.
Targeting these receptors offers a potential strategy for developing anti-infective agents.
These lectins have counteracting effects during infections by certain pathogens.

Purpose of the Study:

To investigate the development of selective DC-SIGN targeting agents.
To explore the potential of multivalent sp2-iminosugar-containing mannobioside analogs as biomimetic ligands.
To assess the selectivity of these analogs towards DC-SIGN over langerin.

Main Methods:

Synthesis of multivalent sp2-iminosugar-containing mannobioside analogs.
Evaluation of binding affinity and selectivity towards DC-SIGN and langerin.
Utilizing the canonical binding mode of high-mannose oligosaccharide ligands.

Main Results:

The synthesized mannobioside analogs demonstrated complete selectivity for DC-SIGN.
These analogs effectively mimicked the binding of natural high-mannose oligosaccharide ligands.
The compounds leveraged the canonical binding mode for selective receptor interaction.

Conclusions:

Multivalent sp2-iminosugar mannobioside analogs can achieve exclusive DC-SIGN targeting.
These findings support the development of DC-SIGN selective agents.
The biomimetic approach offers a promising avenue for novel anti-infective therapies.