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Published on: August 13, 2019
Falsely Elevated Estradiol Results in a 62-Year-Old Male Patient
Gergely Talaber1, Tomas Meisel2, Thord Rosen3
1Unilabs AB, Department of Clinical Chemistry, Skaraborg Hospital, Skövde, Sweden.
Abstract:
Falsely increased estradiol levels can lead to unnecessary tests and therapeutic interventions. Here, we present a case of a 62-year-old man with falsely elevated estradiol, which led to subsequent follow-up testing and prescriptions. Alternative immunoassay testing, in conjunction with Scantibodies' blocking reagents, polyethylene glycol precipitation, and liquid chromatography-tandem mass spectrometry confirmation demonstrated that the falsely elevated estradiol was due to the presence of macro-estradiol. This report emphasizes the importance of recognizing analytical interferences in immunoassays to appropriately manage subsequent testing and patient care.
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