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Periostin: biology and function in cancer
Shima Dorafshan1,2, Mahdieh Razmi2, Sadegh Safaei1,2
1Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Cancer Cell International
|October 12, 2022
Summary
Periostin (POSTN), an extracellular matrix protein, promotes tumor growth by interacting with cell receptors. This review explores POSTN
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Periostin (POSTN) is a matricellular protein involved in normal tissue development and pathological conditions.
- Extracellular matrix proteins, including POSTN, play critical roles in the tumor microenvironment.
- POSTN is essential for bone, tooth, and cardiac development.
Purpose of the Study:
- To summarize current data on periostin's structure, isoforms, expression, function, and regulation.
- To emphasize POSTN's association with cancer progression.
- To explore potential therapeutic strategies targeting POSTN.
Main Methods:
- Literature review of recent studies on periostin.
- Analysis of POSTN's role in normal and cancerous tissues.
- Exploration of POSTN's interactions with cell-surface receptors and signaling pathways.
Main Results:
- Periostin interacts with integrins and other cell-surface receptors, promoting tumor growth.
- POSTN signaling is implicated in cancer cell survival, epithelial-mesenchymal transition (EMT), invasion, and metastasis.
- POSTN expression and function are altered in various cancers.
Conclusions:
- Periostin is a key regulator of cancer progression and metastasis.
- Targeting periostin presents a promising therapeutic avenue for cancer treatment.
- Further research is needed to fully elucidate POSTN's role and develop effective therapies.
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