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PrEP Indications and PrEP Knowledge, Access, and Interest Among Individuals With HCV
Kristi C Hill1,2, Sarah M Kattakuzhy3, Rachel Silk3
1Harvard Medical School, Boston, Massachusetts, USA.
Open Forum Infectious Diseases
|October 13, 2022
Summary
Many individuals with Hepatitis C (HCV) have indications for pre-exposure prophylaxis (PrEP), but awareness and uptake remain low. Improved implementation of PrEP is needed for this population.
Area of Science:
- Infectious Diseases
- Public Health
- Epidemiology
Background:
- Hepatitis C (HCV) and Human Immunodeficiency Virus (HIV) share overlapping risk factors and transmission networks.
- Individuals with HCV may benefit from pre-exposure prophylaxis (PrEP) due to these shared risks.
Purpose of the Study:
- To assess the prevalence of PrEP indications among individuals with HCV monoinfection.
- To evaluate PrEP awareness, interest, and access within this population.
Main Methods:
- Observational study (GRAVITY) analyzing epidemiologic survey data from HCV-monoinfected patients.
- Bivariate and multivariable analyses to determine associations between PrEP indications and awareness, access, and interest.
Main Results:
- 35% of 314 HCV-monoinfected participants had an indication for PrEP (drug use, sexual, or both).
- Only 27% had heard of PrEP, 10% were offered it, and 2% were currently using it.
- PrEP awareness was associated with study site, race, age, and sexual indication, but only study site remained significant in regression analysis.
Conclusions:
- Prevalence of PrEP indications is high among individuals with HCV.
- Low awareness, offering, and current use of PrEP highlight a gap in implementation.
- Enhanced PrEP strategies are necessary for people with HCV.
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