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Updated: Aug 26, 2025

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
[Central nervous system infections and targeted therapies: what to consider]
Fiona Marison1, Véronique Erard2
1Service d'hématologie, Hôpital de l'Île-Bern, 3010 Berne.
Abstract:
The development of targeted therapies has revolutionized the approach to immunosuppression in several medical specialties. While the prescriber of these therapies is familiar with these agents, both the general internist and the infectious disease specialist must deal with the consequences of these products. Encephalitis, for which prompt and appropriate management is paramount, is a challenge in the patient undergoing immunomodulatory therapies because of its atypical presentation, the involvement of particular germs and the potential brain toxicity of some immunomodulatory treatments. This article outlines the mechanisms of action of some targeted therapies and reviews the associated brain infections.
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