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Updated: Aug 26, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Catalytic Reversible (De)hydrogenation To Rotate a Chemically Fueled Molecular Switch
Enzo Olivieri1, Na Shao1, Roselyne Rosas2
1Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France.
Abstract:
We report here the development of a rotating molecular switch based on metal-catalyzed reversible (de)-hydrogenation. Under an argon atmosphere, acceptorless dehydrogenation induces a switch from an alcohol to a ketone, while reversing to a hydrogen pressure switches back the system to the alcohol. Based on a tolane scaffold, such reversible (de)-hydrogenation enables 180° rotation. The absence of waste accumulation in a switch relying on chemical stimuli is of great significance and could potentially be applied to the design of efficient complex molecular machines.
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