Targeting lncRNA/Wnt axis by flavonoids: A promising therapeutic approach for colorectal cancer

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Shuai Han1, Yunyun Cao1, Tianyi Guo1

  • 1Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, People's Republic of China.

Phytotherapy Research : PTR
|October 13, 2022
PubMed

Insights

Flavonoids show promise in targeting the lncRNA/Wnt axis for colorectal cancer (CRC) therapy. This review explores their potential in developing nutrition-based prevention strategies for CRC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Nutritional Science

Background:

  • Colorectal cancer (CRC) remains a significant health concern despite advances in understanding its causes.
  • Wnt/β-Catenin pathway mutations and long non-coding RNAs (lncRNAs) are key players in CRC initiation, progression, and metastasis.
  • Current therapeutic strategies for CRC are still insufficient, necessitating novel approaches.

Purpose of the Study:

  • To systematically review the role of flavonoids in targeting the lncRNA/Wnt axis for colorectal cancer (CRC) therapy.
  • To explore the potential of flavonoids as a therapeutic strategy for CRC based on epigenetic mechanisms.
  • To provide insights for developing nutrition-oriented preventive strategies for CRC.

Main Methods:

  • Literature review and systematic summary of existing research on flavonoids, lncRNAs, and the Wnt/β-Catenin pathway in CRC.
  • Analysis of scientific evidence linking flavonoid compounds to the modulation of lncRNA and Wnt/β-Catenin signaling in CRC.
  • Synthesis of findings regarding the therapeutic and preventive potential of flavonoids in CRC.

Main Results:

  • Flavonoids demonstrate the ability to target the lncRNA/Wnt axis, a crucial pathway in colorectal cancer.
  • These natural compounds show potential in inhibiting CRC carcinogenesis and reducing treatment side effects.
  • Evidence suggests flavonoids can modulate epigenetic mechanisms involved in CRC development.

Conclusions:

  • Targeting the lncRNA/Wnt axis with flavonoids presents a promising therapeutic avenue for colorectal cancer.
  • Flavonoids offer a potential strategy for developing nutrition-based preventive measures against CRC.
  • Further epidemiological and clinical trials are essential to validate the efficacy of flavonoid-based interventions for CRC therapy and prevention.
Keywords:
colorectal cancerepigenetic therapyflavonoidslncRNA/Wnt axis

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