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Updated: Aug 26, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Salivary gland tumors-an overview : Advances in molecular characterization: Part I]
Niels J Rupp1,2, Sandra N Freiberger3
1Institut für Pathologie und Molekularpathologie, Universitätsspital Zürich, Universität Zürich, Zürich, Schweiz. niels.rupp@usz.ch.
Abstract:
In recent years, the characterization of salivary gland tumors has undergone a major transformation. Morphologically defined entities could to a large extent also be characterized molecularly with an often distinct genotype. The first part of this article reviews the advances in the molecular characteristics of mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, secretory carcinoma, intraductal carcinoma, and hyalinizing clear cell carcinoma. The molecular genotype can be particularly useful in classifying unusual morphologic variants. Recurrent NTRK or RET gene fusions can be used not only as a diagnostic tool but also for potential targeted therapy.
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