Related Experiment Video
Updated: Aug 25, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Bio-Physics Approach to Urinary Incontinence Disabilities.
Loris Prosperi1, Giovanni Barassi2, Maurizio Panunzio2
1Center for Physiotherapy, Rehabilitation and Re-Education (Ce.Fi.R.R.), Venue "G.d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
This study found that combining manual therapy with mechano-acoustic vibrations improved urinary incontinence symptoms and reduced its impact. While not all measures showed significant change, the integrated approach offers a promising non-pharmacologic option for women.
Area of Science:
- Pelvic floor physical therapy
- Rehabilitation medicine
- Women's health
Background:
- Urinary incontinence (UI) and pelvic floor dysfunctions significantly impact quality of life.
- Non-pharmacologic management of UI is effective and beneficial.
- This study explores an integrated therapy approach for nonspecific UI.
Purpose of the Study:
- To evaluate the effectiveness of combining manual therapy and focused mechano-acoustic vibrations for women with nonspecific UI.
- To assess improvements in UI symptoms and psychosocial impact.
Main Methods:
- A retrospective observational study of 15 women with UI.
- Intervention involved 8 weeks of twice-weekly integrated therapy.
- Outcome measures included the Pelvic Floor Disability Index (PFDI-20), Pelvic Floor Impact Questionnaire-7 (PFIQ-7), and MyotonPRO.
Main Results:
- Significant reductions in PFDI-20 and PFIQ-7 scores were observed between admission (T0) and 12 weeks (T2).
- No significant improvements were noted in MyotonPRO parameters.
- ANOVA confirmed significant differences in questionnaire results, but not in MyotonPRO variables.
Conclusions:
- The integrated therapy of manual therapy and mechano-acoustic vibrations improved UI symptoms and reduced psychosocial impact.
- Despite limitations and some non-significant findings, this approach shows promise.
- Further research is needed to establish the long-term efficacy of this integrated treatment for UI.
Related Concept Videos
Physiology of Urine Formation
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
Physiology of the Genitourinary System III: Urine Concentration and Dilution
Urinary Tract Infection II: Pathophysiology
The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
Disorders of the Urinary System
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

