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Upconversion Nanomaterials in Bioimaging and Biosensor Applications and Their Biological Response
Zayakhuu Gerelkhuu1,2, Yong-Ill Lee3,4, Tae Hyun Yoon1,2,5
1Department of Chemistry, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Nanomaterials (Basel, Switzerland)
|October 14, 2022
Summary
Upconversion nanomaterials (UCNMs) offer unique optical properties for biomedical applications like drug delivery and bioimaging. This review covers their mechanisms, synthesis, applications, and biological responses, addressing clinical prospects and challenges.
Area of Science:
- Nanomaterials Science
- Biomedical Engineering
- Optical Physics
Background:
- Upconversion nanomaterials (UCNMs) possess unique optical properties, including large anti-Stokes shifts and non-photobleaching.
- These characteristics make UCNMs highly suitable for diverse biomedical applications.
Purpose of the Study:
- To review the mechanisms, synthesis, and biological applications of UCNMs.
- To discuss the biological responses and toxicity associated with UCNMs.
- To explore the clinical prospects and future challenges of UCNMs in medicine.
Main Methods:
- Literature review of upconversion mechanisms and synthesis techniques.
- Analysis of UCNM applications in drug delivery, bioimaging, biosensing, and photodynamic therapy.
- Evaluation of biological responses, toxicity, and intracellular mechanisms of UCNMs.
Main Results:
- UCNMs exhibit promising potential for integrated biomedical applications.
- Understanding UCNM biological responses and toxicity is crucial for clinical translation.
- Significant opportunities exist for UCNMs in both biological research and clinical settings.
Conclusions:
- UCNMs are versatile tools with significant potential in various biomedical fields.
- Further research into UCNM safety and efficacy is needed for clinical adoption.
- The future of UCNMs in medicine holds promise, contingent on overcoming current challenges.
