Breastfeeding in Phenylketonuria: Changing Modalities, Changing Perspectives
Juri Zuvadelli1, Sabrina Paci1, Elisabetta Salvatici1
1Clinical Department of Pediatrics, San Paolo Hospital, ASST Santi Paolo E Carlo, University of Milan, Via Antonio di Rudinì 8, 20142 Milan, Italy.
Nutrients
|October 14, 2022
Summary
For infants with phenylketonuria (PKU), a specific breastfeeding method using Phe-free formula before human milk (HM) can extend breastfeeding duration. This approach supports HM benefits for PKU patients and mothers.
Area of Science:
- Pediatrics
- Nutritional Science
- Metabolic Disorders
Background:
- Phenylketonuria (PKU) management requires strict control of phenylalanine (Phe) intake.
- Human milk (HM) offers significant benefits, particularly when breastfeeding is prolonged.
- Optimal breastfeeding strategies for infants with PKU are not well-defined in current literature.
Purpose of the Study:
- To evaluate different nutritional approaches for newborns and infants diagnosed with PKU.
- To determine if specific feeding methods influence the duration of breastfeeding in PKU infants.
Main Methods:
- Retrospective review of feeding data from 42 infants diagnosed with PKU.
- Analysis of three distinct breastfeeding approaches used in conjunction with Phe-free formula supplementation.
- Comparison of breastfeeding duration across different intervention groups.
Main Results:
- 67% of the studied PKU infants were breastfed.
- The duration of breastfeeding was significantly longer in infants who received a pre-measured amount of Phe-free formula before HM.
- The specific feeding approach demonstrated an impact on breastfeeding duration.
Conclusions:
- This study suggests a specific method for optimizing breastfeeding in infants with PKU.
- Administering Phe-free formula prior to HM may prolong breastfeeding duration.
- These findings encourage greater awareness of appropriate breastfeeding modalities to maximize benefits for PKU infants and their mothers.
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