Progress in Biosensors for the Point-of-Care Diagnosis of COVID-19
1Faculty of Military Health Sciences, University of Defense, Trebesska 1575, CZ-50001 Hradec Kralove, Czech Republic.
Insights
Early diagnosis of COVID-19 is crucial. Biosensors offer a sensitive and accurate alternative to current point-of-care tests for detecting the virus and its components.
Area of Science:
- Biomedical Engineering
- Infectious Diseases
- Analytical Chemistry
Background:
- Coronavirus disease 2019 (COVID-19) is a highly virulent infection causing a global pandemic.
- Early diagnosis is critical for minimizing disease impact and transmission.
- Point-of-care tests, particularly lateral flow immunoassays, are vital diagnostic tools.
Purpose of the Study:
- To review recent advancements in point-of-care diagnostic tests for COVID-19.
- To explore the development of biosensors as advanced diagnostic alternatives.
- To cover biosensors targeting viral components, genetic information, and antibodies.
Main Methods:
- Review of recent scientific literature on COVID-19 diagnostics.
- Analysis of biosensor technology for disease detection.
- Focus on lateral flow tests and emerging biosensor platforms.
Main Results:
- Biosensors demonstrate high sensitivity and accuracy for detecting COVID-19.
- These devices offer a promising alternative to existing point-of-care and laboratory methods.
- Advancements include targeting specific viral parts, genetic material, and host antibodies.
Conclusions:
- Biosensors represent a significant advancement in COVID-19 diagnostics.
- They offer potential for rapid, accurate, and accessible disease detection.
- Continued development of biosensors is crucial for pandemic preparedness.
Abstract:
Coronavirus disease 2019 (COVID-19) is a highly virulent infection that has caused a pandemic since 2019. Early diagnosis of the disease has been recognized as one of the important approaches to minimize the pathological impact and spread of infection. Point-of-care tests proved to be substantial analytical tools, and especially lateral flow immunoassays (lateral flow tests) serve the purpose. In the last few years, biosensors have gained popularity. These are simple but highly sensitive and accurate analytical devices composed from a selective molecule such as an antibody or antigen and a sensor platform. Biosensors would be an advanced alternative to current point-of-care tests for COVID-19 diagnosis and standard laboratory methods as well. Recent discoveries related to point-of-care diagnostic tests for COVID-19, the development of biosensors for specific antibodies and specific virus parts or their genetic information are reviewed.
