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Updated: Aug 25, 2025
Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
Published on: October 17, 2017
Elevated monocyte to high-density lipoprotein cholesterol ratio correlates with clinical severity in acute
You-Fan Peng1, Miao Luo2, Qing-Song Zhang1
1Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Abstract:
While monocyte to high-density lipoprotein cholesterol ratio (MHR) has been reported to be associated with nervous system lesions, the role of MHR has not been determined in patients with Guillain-Barré Syndrome (GBS). The purpose of our study was to explore the role of MHR in patients with GBS. A total of 52 GBS patients were involved in the study retrospectively, including patients with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN), and acute motor sensory axonal neuropathy (AMSAN). We used Hughes Functional Grading Scale (HFGS) score to evaluate functional status in GBS patients. Among patients with different subtypes of GBS, MHR was significantly elevated in those with demyelination compared to patients without demyelination (p < 0.001); AIDP patients had an increased MHR compared with AMAN or AMSAN patients (p = 0.001; p = 0.013). There was a positive correlation between MHR and HFGS score (r = 0.463, p = 0.006) in AIDP patients, but not in AMAN or AMSAN. Multiple linear regression analysis revealed that MHR was independently associated with HFGS score (beta = 0.405, p = 0.013) in AIDP patients. Our study suggests that MHR as an inflammatory marker is elevated in patients with AIDP compared to AMAN or AMSAN patients, while MHR has a positive correlation with clinical severity in AIDP patients, suggesting that MHR may provide an additional information to reflect the pathophysiology of AIDP.
Insights
The monocyte to high-density lipoprotein cholesterol ratio (MHR) is elevated in Guillain-Barré Syndrome (GBS) patients with demyelination, particularly acute inflammatory demyelinating polyradiculoneuropathy (AIDP), and correlates with disease severity.
Area of Science:
- Neurology
- Biochemistry
- Inflammation
Background:
- The monocyte to high-density lipoprotein cholesterol ratio (MHR) is linked to nervous system disorders.
- Its role in Guillain-Barré Syndrome (GBS) remains unclear.
Purpose of the Study:
- To investigate the role and clinical significance of MHR in GBS patients.
- To compare MHR levels across different GBS subtypes.
Main Methods:
- Retrospective study of 52 GBS patients.
- Categorization into acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN), and acute motor sensory axonal neuropathy (AMSAN).
- Assessment of functional status using the Hughes Functional Grading Scale (HFGS).
Main Results:
- MHR was significantly higher in GBS patients with demyelination versus without.
- AIDP patients exhibited elevated MHR compared to AMAN and AMSAN patients.
- MHR positively correlated with HFGS scores in AIDP patients, indicating a link to clinical severity.
Conclusions:
- MHR is elevated in AIDP, suggesting it reflects inflammatory processes in this GBS subtype.
- MHR may serve as a biomarker for disease severity in AIDP.
- Further research can explore MHR's role in GBS pathophysiology.
