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Updated: Aug 25, 2025

Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
The Effect of White Noise and Brahms' Lullaby on Pain in Infants during Intravenous Blood Draw: A Randomized
Insights
White noise and Brahms' lullaby effectively reduced pain and crying time in infants during blood draws. These auditory interventions offer a non-pharmacological approach to pain management in pediatric settings.
Area of Science:
- Pediatrics
- Pain Management
- Neonatal Care
Background:
- Intravenous blood draws are a common and often painful procedure for infants.
- Effective pain management strategies are crucial for infant well-being during medical procedures.
- Non-pharmacological interventions are increasingly explored for their safety and efficacy in pediatric pain relief.
Purpose of the Study:
- To investigate the efficacy of white noise and Brahms' lullaby in managing pain in infants undergoing intravenous blood draws.
- To compare the pain and crying duration in infants exposed to white noise, Brahms' lullaby, or a control condition.
Main Methods:
- An experimental, randomized controlled trial was conducted with 59 infants aged 0-12 months.
- Infants were randomly assigned to three groups: white noise, Brahms' lullaby, or control.
- Pain was assessed using the Neonatal Infant Pain Scale (NIPS), with measurements taken before, during, and after the procedure. Crying time was also recorded.
Main Results:
- Infants in the white noise and Brahms' lullaby groups exhibited lower NIPS scores compared to the control group, particularly during and after the procedure (P < .05).
- Crying time was significantly reduced in the white noise and Brahms' lullaby groups after the procedure compared to the control group (P < .05).
Conclusions:
- Both white noise and Brahms' lullaby demonstrated effectiveness in reducing pain in infants during intravenous blood draws.
- These auditory interventions represent a viable non-pharmacological method for mitigating procedural pain in infants.
Objective:
This study investigates the effects of white noise and Brahms' lullaby in managing pain in infants who were administered with intravenous blood draws in a pediatric blood-sampling unit.
Design:
This study was an experimental, randomized controlled trial.
Setting:
This study was conducted on 0-12-month-old infants admitted to a pediatric blood-sampling unit of a university hospital in Turkey between July and October 2019.
Participants:
The sample comprised 59 infants 0-12 months of age. The infants were randomly assigned to three groups: (a) white noise, (b) Brahms' lullaby, and (c) control.
Outcome Measures:
We evaluated the pain of the infants according to the Neonatal Infant Pain Scale (NIPS). We measured their pain and crying time before, during, and after the procedure.
Results:
The means of the NIPS scores of the infants in the white noise and Brahms' lullaby groups were lower than that of the control group before, during, and after the procedure. The means of the NIPS scores of the infants in the white noise and Brahms' lullaby groups were significantly lower than that of the control group during and after the procedure (P < .05). The crying time of the infants in the white noise and Brahms' lullaby groups were significantly lower than that of the control group after the procedure (P < .05).
Conclusion:
The white noise and Brahms' lullaby used during the intravenous blood draw procedure reduced the pain of infants.
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