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Ion-Pairing Catalysis in Stereoselective, Light-Induced Transformations
Tobias E Schirmer1, Burkhard König1
1Institute of Organic Chemistry, University of Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany.
Journal of the American Chemical Society
|October 14, 2022
Summary
Asymmetric ion-pairing catalysis is emerging in photoredox catalysis. This perspective reviews recent advances in light-driven stereoselective radical reactions using ion-pairing strategies.
Area of Science:
- Organic Chemistry
- Catalysis
- Photochemistry
Background:
- Photoredox catalysis has seen broad adaptation of asymmetric induction strategies from traditional reactions.
- Asymmetric ion-pairing catalysis is underexplored in light-driven reactions.
- Bridging ion-pairing and photoredox catalysis is a key challenge.
Purpose of the Study:
- To provide an overview of asymmetric ion-pairing catalysis in photoredox reactions.
- To highlight recent examples and strategies in this niche field.
- To discuss applications in stereoselective radical transformations.
Main Methods:
- Literature review of recent studies.
- Analysis of strategies for asymmetric induction in ion-pairing photoredox catalysis.
- Synthesis of examples at the interface of ion-pairing and photoredox catalysis.
Main Results:
- Numerous examples demonstrate the potential of asymmetric ion-pairing in photoredox catalysis.
- Key strategies for achieving stereoselectivity in radical ion-pairing reactions are identified.
- The application scope in stereoselective transformations is expanding.
Conclusions:
- Asymmetric ion-pairing catalysis is a promising but niche area in photoredox chemistry.
- Further development is needed to broaden its application.
- This field offers unique opportunities for stereoselective radical synthesis.
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