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Medication habits among persons with multiple sclerosis.

Efrat Neter1, Lea Glass-Marmor2, Anat Wolkowitz2

  • 1Department of Behavioral Sciences, Ruppin Academic Center, Israel.

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PubMed
Summary

Medication habits in relapsing remitting multiple sclerosis (PwRRMS) increase over time, but are not fully ingrained. Interventions targeting habit formation can improve adherence to disease-modifying treatments (DMTs).

Keywords:
Disease modifying therapyHabitMedication adherenceMultiple sclerosisPatient reported outcomesPersistence

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Area of Science:

  • Neurology
  • Behavioral Science
  • Pharmacology

Background:

  • Habitual behavior is a component of medication adherence.
  • Previous studies have not prospectively examined habit formation in relation to disease-modifying treatments (DMTs) for persons with relapsing-remitting multiple sclerosis (PwRRMS).

Purpose of the Study:

  • To examine habit dimensions (repetition, lack of awareness, lack of control) over time and by route of administration (oral vs. injectable).
  • To assess the association of habit dimensions with medication adherence, persistence, and perceptions.

Main Methods:

  • Prospective study of 140 PwMS in their first year of DMT treatment.
  • Data collected at baseline, 6 months, and 12 months.
  • Assessed medication habits, perceptions, adherence, and persistence.

Main Results:

  • Repetition and lack of awareness dimensions increased over time; lack of control did not.
  • No significant differences in habit dimensions based on administration route.
  • Repetition was associated with adherence and predicted future persistence.
  • Medication concerns were negatively associated with repetition.

Conclusions:

  • Medication-taking habits evolve over time in PwRRMS, with increased repetition and reduced awareness.
  • Habit formation is not complete, suggesting potential for interventions.
  • Targeted interventions can enhance medication adherence and improve disease outcomes.