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Next generation T cell therapies for solid cancers

John B Haanen1, Ton N Schumacher2

  • 1Division of Medical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; Department of Clinical Oncology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Med (New York, N.Y.)
|October 15, 2022
PubMed

Insights

Researchers enhanced tumor-infiltrating lymphocytes for treating metastatic melanoma by knocking out CISH. This creates a more functional cell product for improved clinical benefit in cancer immunotherapy.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Tumor-infiltrating lymphocytes (TILs) offer clinical benefit in metastatic melanoma.
  • Current TIL products are poorly defined and have variable antitumor activity.

Purpose of the Study:

  • To develop a more effective TIL product for clinical testing.
  • To enhance the functionality of tumor-reactive T cells.

Main Methods:

  • Knockout of CISH (cytokine-inducible SH2-containing protein) in T cells.
  • Generation of a novel cell product for cancer immunotherapy.

Main Results:

  • Creation of highly functional tumor-reactive T cells.
  • Development of a cell product suitable for clinical testing.

Conclusions:

  • Knocking out CISH is a promising strategy to improve TIL therapy for metastatic melanoma.
  • This approach could lead to more consistent and potent antitumor activity in cancer patients.

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