Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Enteral Nutrition I: Orogastric and Nasogastric Feeding01:26

Enteral Nutrition I: Orogastric and Nasogastric Feeding

Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood loss due to diagnostic testing in extremely preterm infants in 22 European countries: a prospective observational study.

EClinicalMedicine·2026
Same author

Developmental maturation of intestinal junctional complexes in preterm infants.

Tissue barriers·2026
Same author

Early antibiotic exposure and vaccine immune responses in preterm infants: potential sex-specific differences.

Gut microbes·2026
Same author

The impact of central venous catheter use on long-term growth and neurobehavioral outcome in preterm children born < 29 weeks of gestation.

Molecular and cellular pediatrics·2026
Same author

Surfactant administration via supraglottic airway in premature infants (SALSA): a survey-based assessment of current procedural practice.

Archives of disease in childhood. Fetal and neonatal edition·2026
Same author

Intersectionality of early developmental risks and resilience after preterm birth.

Molecular and cellular pediatrics·2026

Related Experiment Video

Updated: Jun 18, 2026

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

Rethinking parenteral nutrition as supportive therapy for neonatal sepsis.

Ole Bæk1, Christoph Härtel2, Claus Klingenberg3

  • 1Comparative Pediatrics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; BRIDGE Translational Excellence Programme, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Med (New York, N.Y.)
|June 16, 2026
PubMed
Summary

Optimizing parenteral nutrition (PN) for neonatal infections is crucial. Alternative macronutrients, not just glucose, may improve immune response, reduce organ injury, and enhance survival in vulnerable newborns.

Keywords:
immunometabolisminfectionneonatal sepsisnutritionparenteral nutritionsepsistranslation to patients

More Related Videos

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Related Experiment Videos

Last Updated: Jun 18, 2026

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Area of Science:

  • Neonatal immunology
  • Medical nutrition therapy
  • Immunometabolism

Background:

  • Severe neonatal infections pose significant risks, especially for preterm infants.
  • Current guidelines for parenteral nutrition (PN) during infection in vulnerable newborns are lacking.
  • Optimizing nutritional support is critical for managing infection and improving outcomes in neonates.

Purpose of the Study:

  • To highlight the need for evidence-based PN guidelines during neonatal infections.
  • To explore how nutritional strategies can modulate immune responses and clinical outcomes.
  • To propose alternative macronutrient approaches beyond glucose-rich PN.

Main Methods:

  • Review of immunometabolism and translational preclinical models.
  • Analysis of host metabolic pathways during infection.
  • Conceptual framework for therapeutic nutritional interventions.

Main Results:

  • Conventional glucose-rich PN may exacerbate inflammation via glycolysis.
  • Alternative macronutrients (galactose, amino acids, ketone bodies) may promote balanced immunity.
  • Targeted nutrition can potentially reduce organ injury and improve survival.

Conclusions:

  • Neonatal nutrition during infection should be considered a therapeutic intervention.
  • Alternative macronutrient strategies warrant investigation for neonatal sepsis.
  • Clinical trials are needed to develop targeted PN protocols for infected, vulnerable newborns.