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Updated: Aug 25, 2025

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine
Published on: June 24, 2019
A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development
Luisa Cervantes-Barragan1, Marco Colonna2
1Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Abstract:
CD4+ intraepithelial lymphocytes (CD4IEL) are tissue-resident T cells with cytotoxic and regulatory properties; together with peripheral regulatory T cells, they control intestinal inflammation. Recently, Bousbaine and colleagues identified a microbiota-derived conserved antigen that induces CD4IEL differentiation and promotes their regulatory function, attenuating the severity of murine colitis.
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