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COVID-19 in Chronic Granulomatosis Disease: A Case Report

Hossein Esmaeilzadeh1, Seyed Sina Dehghani2, Babak Shahhoseini3

  • 1Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. esmailzadeh_ho@yahoo.com.

Iranian Journal of Allergy, Asthma, and Immunology
|October 16, 2022
PubMed

Insights

Two patients with Chronic Granulomatous Disease (CGD) experienced severe Coronavirus Disease 2019 (COVID-19) infections. This challenges the assumption that CGD offers protection against severe viral illnesses, suggesting a unique COVID-19 pathogenesis.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Genetics

Background:

  • Coronavirus Disease 2019 (COVID-19) is a global pandemic.
  • Chronic Granulomatous Disease (CGD) involves impaired phagocyte function, leading to recurrent infections.
  • CGD patients typically have normal viral immunity, and impaired neutrophil function was hypothesized to be protective against severe COVID-19.

Keywords:
Chronic granulomatous diseaseCoronavirus disease 2019

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