Computed tomography bone density variations in oncological patients undergoing antiresorptive medication
W-H Yanaguizawa1, F-B Barros, S Kobayashi-Velasco
1School of Dentistry, University of São Paulo Av. Prof. Lineu Prestes 2227 Zip code: 05508-000, São Paulo, SP, Brazil mgpcaval@usp.br.
Medicina Oral, Patologia Oral Y Cirugia Bucal
|October 16, 2022
Summary
Antiresorptive medication increased bone density in the jaw and cervical vertebrae of cancer patients. Computed tomography (CT) analysis can help predict disease progression in patients undergoing this therapy.
Area of Science:
- Medical Imaging
- Oncology
- Pharmacology
Background:
- Antiresorptive medications are used in cancer patients.
- Osteonecrosis of the jaw is a potential side effect.
- Monitoring bone density is crucial for risk assessment.
Purpose of the Study:
- To compare jaw and cervical vertebrae bone density in patients on antiresorptive medication versus controls.
- To aid radiologists and clinicians in predicting risks and monitoring osteonecrosis.
Main Methods:
- Computed tomography (CT) analysis of bone density using Hounsfield scale values.
- Comparison of bone density in the mandible and C2 cervical vertebrae.
- Statistical analysis including Mann-Whitney U test.
Main Results:
- Patients on antiresorptive medication showed increased bone density in both jaw bone (p=0.021) and cervical vertebrae (p=0.002).
- Increased bone density was observed in the jaw and cervical vertebrae regardless of monthly or quarterly medication schedules.
Conclusions:
- CT is a potentially useful method for detecting alterations related to antiresorptive therapy.
- CT analysis may serve as a tool for predicting disease progression in patients undergoing antiresorptive treatment.
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