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Ex Utero Culture of Mouse Embryos from Pregastrulation to Advanced Organogenesis
Published on: October 19, 2021
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In vitro models of pre- and post-gastrulation embryonic development
1Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8501, Japan.
Current Opinion in Genetics & Development
|October 16, 2022
Summary
Pluripotent stem cells (PSCs) are revolutionizing developmental biology by enabling in vitro models of early embryonic development. These models offer new insights into how form and function emerge during development.
Area of Science:
- Developmental Biology
- Stem Cell Research
Background:
- Pluripotent stem cells (PSCs) derivation and culture are linked to advances in in vitro fertilization and blastocyst culture.
- Insights from developmental biology studies in model organisms have enabled the derivation of various cell types from PSCs.
Purpose of the Study:
- To summarize recent advances and breakthroughs in PSC-based in vitro models of early embryonic development.
- To highlight the use of PSCs in reconstituting and analyzing complex aspects of mouse and human embryonic development.
Main Methods:
- Review of recent literature on PSC-based in vitro models.
- Analysis of studies utilizing PSCs to model embryonic development.
Main Results:
- PSCs are increasingly used to model early embryonic development in vitro.
- These bottom-up approaches provide novel insights into core developmental processes.
- PSC models aid in deciphering the biological principles underlying the emergence of form and function.
Conclusions:
- PSC-based in vitro models represent a rapidly growing field with significant potential.
- These models offer a powerful tool for understanding embryonic development.
- Future research directions in PSC-based developmental modeling.
