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Bioactive Compounds from Medicinal Mushrooms.

Jingsong Zhang1, Na Feng2, Yangfang Liu2

  • 1Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, People's Republic of China. syja16@saas.sh.cn.

Advances in Biochemical Engineering/Biotechnology
|October 16, 2022
PubMed
Summary
This summary is machine-generated.

This review summarizes active compounds and biological activities of medicinal mushrooms like Ganoderma and Cordyceps. These fungi offer potential health benefits, including immune support and anti-tumor effects.

Keywords:
BioactivityCordyceps spp.Ganoderma spp.Hericium spp.HeteropolysaccharideHomopolysaccharidePhellinus spp.

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Area of Science:

  • Mycology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Medicinal mushrooms such as Ganoderma spp., Hericium spp., Phellinus spp., and Cordyceps spp. have been utilized for centuries in traditional medicine.
  • These fungi are recognized as rich sources of bioactive compounds with diverse therapeutic properties.
  • Understanding their chemical constituents and biological activities is crucial for developing novel pharmaceutical applications.

Purpose of the Study:

  • To systematically review the research progress on active compounds found in selected medicinal mushrooms.
  • To summarize the known biological activities associated with these compounds.
  • To highlight the therapeutic potential of these mushrooms in various health areas.

Main Methods:

  • Literature search of scientific databases (e.g., PubMed, Scopus) for studies on Ganoderma, Hericium, Phellinus, and Cordyceps.
  • Identification and categorization of major active compounds reported in these mushrooms.
  • Compilation and analysis of documented biological activities, including immunomodulatory, antitumor, hypoglycemic, hepatoprotective, and neuroprotective effects.

Main Results:

  • Key active compounds identified include polysaccharides, proteins, triterpenes, meroterpenoids, polyphenols, and nitrogen-containing compounds.
  • These compounds exhibit a wide range of biological activities, such as enhancing immune function, inhibiting tumor growth, lowering blood sugar, protecting the liver, and regulating gut microbiota.
  • Significant research progress has been made in elucidating the mechanisms behind these activities.

Conclusions:

  • Medicinal mushrooms like Ganoderma, Hericium, Phellinus, and Cordyceps are valuable sources of bioactive compounds with significant therapeutic potential.
  • Further research into these compounds and their activities could lead to the development of new drugs and health supplements.
  • The findings support the continued investigation and application of these fungi in medicine and wellness.