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Updated: Aug 25, 2025

Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases
Published on: November 8, 2024
Successfully treated urethral condyloma acuminatum utilizing intraurethral self-application of 5-fluorouracil via
Jacqueline Zillioux1, Giovanna Leone2, Howard B Goldman1,3
1Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Abstract:
Condyloma acuminatum is a benign genital lesion associated with low-risk human papillomavirus subtypes. Approximately 20% of HPV-associated genital warts occur in the urethra. Topical treatment of urethral condyloma in women can be challenging to treat due to difficulty applying the medication such that it maintains contact with the urethra long enough to be effective. We present a case of a successfully cleared urethral condyloma acuminatum treated via self-application using a Q-tip.
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