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Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Allergic Reactions

Allergic Reactions

Toxic Reactions: Overview

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...

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Related Experiment Video

Updated: Aug 25, 2025

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Hypersensitivity Reaction to Metal: A Bibliometric Study.

Tassia Teles Santana de Macedo¹, Itana Lúcia Azevêdo de Jesus¹, Wilton Nascimento Figueredo²

¹Escola Bahiana de Medicina e Saúde Pública-Enfermagem, Salvador, Bahia, Brazil.

SAGE Open Nursing

|October 17, 2022

Summary

Scientific publications on metal hypersensitivity are limited, primarily from Europe and North America. Research focuses on orthopedic, dermatological, and orthodontic fields, indicating a need for increased investment in this area.

Keywords:

adverse effects allergy bibliometric literature review hypersensitivity metals

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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

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Area of Science:

Medical and Health Sciences
Bibliometrics
Materials Science

Background:

Metal hypersensitivity is a growing clinical concern.
Understanding the research landscape is crucial for advancing the field.
Bibliometric analysis provides insights into scientific output and trends.

Purpose of the Study:

To map the scientific publications on metal hypersensitivity.
To identify leading countries, institutions, and research areas.
To assess the trends and gaps in metal hypersensitivity research.

Main Methods:

Bibliometric study using Scopus database (1946-2020).
Descriptive and quantitative approach.
Data analysis with RStudio and VOSviewer, utilizing bibliometrix and biblioshiny packages.

Main Results:

804 articles published between 1946 and 2020.
Leading countries include Germany, Japan, and the United States.
Research is concentrated in orthopedic, dermatological, and orthodontic specialties.

Conclusions:

Scientific production on metal hypersensitivity is limited.
Research is predominantly from North America and Europe.
Increased investment is needed to advance research in dermatology, dentistry, and orthopedics.