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Link between COVID-19 vaccines and myocardial infarction

Umema Zafar1, Hamna Zafar2, Mian Saad Ahmed3

  • 1Department of Physiology, Khyber Medical College, Peshawar 25000, Pakistan. umema.com@gmail.com.

World Journal of Clinical Cases
|October 17, 2022
PubMed

Insights

This systematic review found many studies linking myocardial infarction (MI) to COVID-19 vaccines, but could not establish a definitive association. Further research is needed to clarify the relationship between COVID-19 vaccination and MI events.

Area of Science:

  • Cardiology
  • Immunology
  • Public Health

Background:

  • Several COVID-19 vaccines are available, including AstraZeneca, Janssen, Moderna, Pfizer, Sinopharm, Sinovac, and Covaxin.
  • Myocardial infarction (MI) is a potential concern following vaccination.

Purpose of the Study:

  • To systematically review and identify associations between COVID-19 vaccines and myocardial infarction (MI).

Main Methods:

  • A systematic review was conducted using MEDLINE, EMBASE, and PakMediNet.
  • Studies were screened based on eligibility criteria, excluding those without MI mention, protocols, genetic, or animal studies.
  • Data from 29 selected studies were extracted.

Main Results:

  • AstraZeneca, Pfizer, and Moderna vaccines were most frequently mentioned in studies reporting MI post-vaccination.
  • MI occurred most often after the first vaccine dose (69%), with ST-elevation MI (44%) and non-ST-elevation MI (26%) reported.
  • The mortality rate following MI was 29%.

Conclusions:

  • While numerous studies suggest a link between COVID-19 vaccinations and MI, a definitive causal association could not be established.
  • The findings highlight the need for continued investigation into potential cardiovascular risks associated with COVID-19 vaccines.
Abstract

Keywords:
AssociationAstraZenecaCovaxinJanssenModernaMyocardial infarctionPfizerSARS-CoV-2 infectionSinovacVaccination

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