Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

119
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
119
Friedman Two-way Analysis of Variance by Ranks01:21

Friedman Two-way Analysis of Variance by Ranks

279
Friedman's Two-Way Analysis of Variance by Ranks is a nonparametric test designed to identify differences across multiple test attempts when traditional assumptions of normality and equal variances do not apply. Unlike conventional ANOVA, which requires normally distributed data with equal variances, Friedman's test is ideal for ordinal or non-normally distributed data, making it particularly useful for analyzing dependent samples, such as matched subjects over time or repeated measures...
279
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

79
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
79
Multiple Regression01:25

Multiple Regression

3.1K
Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
3.1K
Econometric Views (EViews)01:29

Econometric Views (EViews)

216
Econometric Views, often stylized as EViews, is a package that merges statistical analysis with econometric studies. It is designed to provide tools for time series analysis, forecasting, and econometric model simulation. The software originated from MicroTSP software and has evolved significantly since its inception in 1981. The history of EViews is marked by a continuous effort to enhance its computational speed and user interface. It was initially developed for large computing systems but...
216
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

223
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
223

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cellular engagement of the SARS-CoV-2 macrodomain by GS-441524 and enhanced <i>in vitro</i> inhibition by its diphosphorylated metabolite.

RSC chemical biology·2026
Same author

Development of Antagonist Peptides of the Crk/CrkL SH2 Domains by Modifying the Peripheral Amino Acid Residues of the YXXP Motif.

Biochemistry·2026
Same author

Correction for Pfannenstiel et al., "Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication".

mBio·2026
Same author

Transgenic Tobacco Plants Expressing Synthetic Peptides: A Functional and Structural Analysis for Pathogen Resistance.

Plant biotechnology journal·2025
Same author

Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle.

Journal of virology·2025
Same author

Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication.

mBio·2025
Same journal

Elastic functional Cox regression model with shape predictors.

Journal of applied statistics·2026
Same journal

An improved two-stage binary relevance method for multilabel classification.

Journal of applied statistics·2026
Same journal

Classification of multivariate functional data with an application to ADHD fMRI data.

Journal of applied statistics·2026
Same journal

Assessing the performance of longitudinal T-lymphocytes as biomarkers of immune recovery in HIV-infected children with or without TB co-infection.

Journal of applied statistics·2026
Same journal

Sparse long-only Markowitz portfolio optimization.

Journal of applied statistics·2026
Same journal

Homogeneity of multinomial populations when data are classified into a large number of groups.

Journal of applied statistics·2026
See all related articles

Related Experiment Video

Updated: Aug 25, 2025

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.4K

Doubly multivariate linear models with block exchangeable distributed errors and site-dependent covariates.

Timothy Opheim1, Anuradha Roy1

  • 1Department of Management Science and Statistics, The University of Texas at San Antonio, San Antonio, TX, USA.

Journal of Applied Statistics
|October 17, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces Rao's score test (RST) for analyzing multivariate linear models, offering a more accurate and computationally efficient alternative to the likelihood ratio test (LRT) for intercept and slope parameter testing.

Keywords:
62H1062H1562J05Block exchangeable covariance structureMonte Carlo simulationsRao's score testcovariance structure modelshypothesis tests

More Related Videos

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
06:52

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

6.4K
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.7K

Related Experiment Videos

Last Updated: Aug 25, 2025

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.4K
Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
06:52

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

6.4K
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.7K

Area of Science:

  • Statistics
  • Multivariate Analysis
  • Linear Models

Background:

  • Doubly multivariate linear models are essential for analyzing complex datasets with multiple response variables.
  • Testing model parameters in these settings can be computationally intensive and prone to inaccuracies.
  • Existing methods like the likelihood ratio test (LRT) may not be optimal in terms of accuracy and efficiency.

Purpose of the Study:

  • To develop and evaluate Rao's score test (RST) for testing intercept and slope parameters in doubly multivariate linear models.
  • To compare the performance of RST against the LRT statistic.
  • To assess the computational efficiency and accuracy of the proposed RST.

Main Methods:

  • Development of the RST statistic under a block exchangeable covariance structure and multivariate normality.
  • Comparison of RST with LRT using Monte Carlo simulations.
  • Application of the proposed method to an agricultural study involving multiple response variables from multiple trees.

Main Results:

  • Rao's score test (RST) demonstrates significantly higher accuracy compared to the likelihood ratio test (LRT).
  • The RST statistic requires substantially less computation time than the LRT statistic.
  • Simulations confirm the robustness and efficiency of the proposed RST.

Conclusions:

  • Rao's score test (RST) provides a superior method for testing parameters in doubly multivariate linear models.
  • The proposed RST offers a more accurate and computationally efficient alternative for statistical analysis.
  • The method is applicable to real-world scenarios, such as agricultural field studies.